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Wegovy (semaglutide), which was approved in 2021 (it was previously available for diabetes as Ozempic and in an oral form for diabetes as Rybelsus)

Because of oral administration, a higher dosage would be needed for weight loss

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Animal studies use controlled purity, defined dosing, and monitoring that home use cannot replicate, and they still do not answer questions about long-term human exposure, immunogenicity, or rare serious events

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