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This was a study published in the New England Journal of Medicine, October 2024, One Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. Knee osteoarthritis is seen in 20% of those over the age of 45
It may lead to improper dosing, lack of monitoring for side effects, or receiving counterfeit medication
Moreover, it significantly decreases the synthesis of TNF- and IL-6 by activating the AMPK phosphorylation pathway [197]
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Zhang D et al
