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Proton Pump Inhibitors (PPIs): Medications like omeprazole (Prilosec) reduce stomach acid

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Additionally, caffeine can cause the colon to contract (hence its laxative effect in some)

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In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy