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Pharmacological Interventions When lifestyle and dietary modifications are insufficient to control heartburn, pharmacological interventions may be necessary
PKF275-055, an analogue of vildagliptin and a DPP-4 inhibitor, counteracted changes in Na/K-ATPase activity, nerve conduction velocity, and nociceptive thresholds in diabetic rats [50]
J Neural Transmission General Sect 91 : 223240
And before licensing, manufacturers would have to prove that the drug was not only absorbed reliably and consistently via patch, and that these products worked as well as the (proven) injectable versions
This is especially useful during the early weeks of a protocol when doses are often titrated up gradually
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