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Normally, this pathway helps regulate immune responses and cell growth, but in IC, it is often activated abnormally, leading to excessive production of inflammatory cytokines like CCL8 and VEGFD
Gutgesell RM, et al
Physiologically, this lowering of GSH led to increased LDH release ( P = 0.031), consistent with redox activation of ferroptosis and cell death (Figure 4C and refs
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