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Biochem Soc
Start with low concentrations and gradually increase usage to determine what works best for your skin without causing irritation
However, for women with compromised glutathione status (PCOS, IVF conception, gestational blood sugar issues, poor diet, environmental exposures), even therapeutic doses may generate toxic metabolites that affect fetal brain development
Along with the breakdown of antioxidant defenses, there can be dramatic skin membrane lipid peroxidation, triggering ferroptosis, a skin cell death
On this basis, most experts (and therefore, we) err on the side of caution
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