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For patients experiencing diarrhea or abdominal discomfort, morning administration may be preferable, as it allows symptoms to manifest during daytime hours when patients have easier access to bathroom facilities and can manage hydration more effectively
Last reviewed: April 21, 2026 Updated with Phase 3 TRIUMPH-4 data Primary sources: NEJM, Eli Lilly, ClinicalTrials.gov Retatrutide is a triple agonist (GLP-1 + GIP + glucagon) currently in Phase 3 trials, showing stronger early weight loss data
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