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Research studies reflect that 30% to 50% of patients experience gastrointestinal adverse effects with oral semaglutide or Rybelsus

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[22] [23] Before prescribing semaglutide, clinicians should specifically inquire about family history of thyroid cancer, distinguishing MTC from the more common papillary or follicular thyroid cancers, which do not contraindicate GLP-1 receptor agonist therapy

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