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Two separate human clinical trials (ulcerative colitis and multiple sclerosis) proceeded without significant adverse event reporting

Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors

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Samples were centrifuged (13,000 rpm, 1 min, Biofuge Pico, Heraeus, Thermo Fisher Scientific, USA) and the fluorescent signal of nanocarriers was quantified from the supernatant with spectrofluorometer

Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis