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Glutathione reduces oxidative stress, while collagen helps maintain the structural integrity of the skin

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This epigenetic action tends to enhance the expression of genes involved in neurotrophic factor production, synaptic plasticity, and cellular stress resistance

In addition, compared with patients without DN, the abundance of specific genera (such as Hungatella, Bilophila , and Escherichia ) in the gut microbiota of DN patients changed significantly (129)