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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

Free Radic Biol Med

It makes sure the benefits of the first treatment last longer

Some patients have described feelings of fatigue, body aches, or a sense of mental haze before they start noticing the improvements

Thats why B12 injections are often given as treatment