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Notably, methotrexate is preferred for use in patients

I find that for people who have the potential to start a family or to continue their family, it's a very high-risk medication, says Fishman, Thus, the FDA recommends that if you are of child-bearing potential, use a highly-effective method of birth control and talk to your doctor now about weaning off the medication if you consider getting pregnant in the near future

Glutamatergic modulators: the future of treating mood disorders