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It is unfortunate that the combination of patients and clinicians reluctance to use an LAI early in the illness dooms many patients with BD to a potentially avoidable malignant outcome.

The only GHRH analog with clinical marketing authorization (FDA Egrifta 2010 for HIV-associated lipodystrophy, EGRIFTA WR F8 March 2026)

The consequences include progressive shortening of the interval between episodes with every relapse and loss of responsiveness to pharmacotherapy as the illness progresses