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4 encode cytosolic GST and one encodes the microsomal form of GST

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Glutathione protects not only individual cells but also the tissues of the arteries, brain, heart, immune cells, kidneys, lenses of the eyes, liver, lungs, and skin against oxidant damage

EASL Clinical Practice Guidelines: liver transplantation

(9) Rotondi and colleagues have determined that seronegative autoimmune thyroiditis is a less aggressive form of Hashimotos, but nonetheless, the person may still develop hypothyroidism and even progress to other autoimmune conditions, which may or may not have respective positive antibody blood markers (such as seronegative rheumatoid arthritis)