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Circulation , 150 (22), 17811790
Alpha Lipoic Acid is a water and lipid soluble antioxidant required by the mitochondrial matrix pyruvate dehydrogenase complex, which is the starting point of the Krebs or TCA (energy) cycle
95% CI [0.851.29])
Additionally, key pharmacokinetic parameters, such as maximum serum concentrations and time to peak concentration, were markedly improved
these include their overall good safety profile and tolerability, as well as their efficacy in improving glycaemic control, but also, potentially, a small increased risk of acute pancreatitis
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