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Exp Neurobiol 22:1117 Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease

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Slow the progression of kidney disease, reduce the risk of kidney failure (end-stage kidney disease), and decrease the likelihood of death due to cardiovascular disease in adults with type 2 diabetes and chronic kidney disease

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The main practical cautions are its blue-green color (which can tint formulations) and formulation incompatibility with certain other actives notably strong direct-acid vitamin C and high concentrations of exfoliating acids, which can destabilize the copper complex