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Of the 18,010 women who were first prescribed GLP-1 receptor agonists during that time, only 21% had reported using contraception
[2] [3] [4] In patients with or without a history of seizures or epilepsy, withdraw topiramate gradually to minimize the potential for seizures or increased seizure frequency
However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011
It mainly includes increased concentrations of total cholesterol and/or triacylglycerol, as well as decreased concentrations of high-density lipoprotein cholesterol, which is one of the independent risk factors for cardiovascular and cerebrovascular diseases
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