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An important finding from animal studies: the minimally effective weight-based dosages determined in rats (2.5-5 ml per kg) are considerably higher than typical human clinical doses

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PMID 11252898

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However, there can also be an intact BBB which can limit effective treatment by hindering homogeneous uptake of administered therapeutic agents (Figure 2B summarizes the main processes driving BBB disruption, the key factors involved and the role of BBB imaging in neuro-oncology

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