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In models of cerebral hypoxia-ischemia, an increase of DNA methylation was described as an increase in global DNA methylation in the murine cerebral hemispheres, in the promoter of tissue inhibitors of MMP-2 (TIMP2)

Namani et al, 2019)

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In animal models, MOTS-c restored insulin sensitivity in aged and high-fat-fed mice at the muscle level - the same tissue where late-stage GLP-1 protocols often see metabolic slowdown