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331,336 Data from three clinical studies (NCT04083222, NCT03714776, and NCT03101878) demonstrated that compared with placebo, IONIS-AGT-LRx significantly reduces plasma AGT levels, with good tolerability and no notable off-target effects

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Weight Reduction Following Intensive Lifestyle Intervention in Adults with Obesity or Overweight (Study 3) Overview of Study 3 Study 3 (NCT04657016) was an 84-week trial with a 12-week intensive lifestyle intervention lead-in period (Week -12 to Week 0), followed by a 72-week randomized treatment period of ZEPBOUND versus placebo (Week 0 to Week 72) with a standard lifestyle intervention

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The disappointing efficacy of these interventions may be attributed to accumulating evidence suggesting that progression of the disease and lymphocytic infiltration do not necessarily parallel secretory dysfunction [26,27,28,29,30]

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