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Such evidence, however, is supported by many relevant pre-clinical or mechanistic studies highlighting the neuroprotective and anti-inflammatory activity of these medications
doi:10.2337/db10-0474 114
Benefits can include: Lower blood pressure Lower total cholesterol Better liver health for those with metabolic dysfunctionassociated steatotic liver disease (MASLD) Lower blood sugar and reduced diabetes risk Lower risk of kidney disease Tirzepatide and orforglipron are newer drugs that dont yet have results from long-term cardiovascular health trials
The proinflammatory cytokine TNF- enhanced the adhesion of metastatic cells to BECs, by increasing BEC expression of adhesion molecules and increasing the expression of their ligands by cancer cells (Wang et al., 2021)
The combination targets both sides of the GH/IGF-1 axis
