Although our fresh epithelial brushing cell GSH data could have been influenced by nonepithelial (inflammatory) cell contributions, the percentages of these cell types in the brushings are typically less than 10% of total cells, and there was no correlation of BAL inflammatory cells and BAL GSH or GSSG
However, this portal glucose sensor may still require gut input, as these effects appear to be mediated by vagal GLP-1R activation 60,61,62
More importantly, the weight loss caused by tirzepatide in these animals likely contributed to adverse outcomes independently of the drug itself
Meanwhile, tirzepatide might offer more due to its dual-action approach, potentially leading to greater weight loss
Additionally, in a phase I study, treatment of cagrilintide (up to 4.5 mg) combined with semaglutide (2.4 mg) resulted in greater body weight reduction than semaglutide (17% vs