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Mol Cell (2021) 81(18):3691707
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis
Mooz ED et al
JavanMoghadam S, Weihua Z, Hunt KK, Keyomarsi K
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