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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

5-Amino-1MQs ability to shift the bodys energy utilization from storage to active fat-burning helps prevent the buildup of harmful fat, reducing these effects

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NNMT catalyzes the methylation of nicotinamide using methyl donor molecules, contributing to metabolic reactions involved in cellular biochemical processes