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Benefits (Research Focus) IGF-1 receptor activation studied for selective high-affinity agonism of the IGF-1 receptor PI3K/Akt/mTOR signaling investigated for downstream activation of cellular growth and protein synthesis pathways Reduced IGFBP binding explored for the Arg substitution that decreases IGF-binding protein affinity Extended half-life examined for ~20-30 hour bioactivity window compared to ~15 minutes for native IGF-1 Skeletal muscle research researched for satellite cell activation and protein synthesis endpoints in preclinical models What Researchers Look At IGF-1R binding affinity and downstream phosphorylation cascades (IRS-1, Akt, S6K) PI3K/Akt/mTOR pathway activation in muscle and metabolic cell models IGFBP-3 binding affinity and free fraction pharmacokinetics Skeletal muscle protein synthesis and satellite cell activation endpoints Comparative bioactivity versus native IGF-1 and other IGF-1 analogs in cell-culture systems Quick Specs Form: Lyophilized white powder Net Peptide Content: 1 mg per vial Quantity: 1 vial Appearance: White to off-white lyophilizate Reconstitution: Bacteriostatic or sterile water (added by the end researcher) Purity: 99% by HPLC Identity: MS-verified (per COA) Storage: Protect from light Identity Basics Compound: IGF-1 LR3 (Long [Arg] Insulin-like Growth Factor-1) Synonyms: Long R3 IGF-1

The recognition that thrombotic occlusion of a coronary artery results in a wavefront of irreversible myocardial cell injury extending from the subendocardium to the subepicardium in a time-dependent fashion led to the introduction of reperfusion therapy for myocardial infarction.1 However, restoration of blood flow to previously ischemic myocardium results in the so-called ischemia/reperfusion (I/R) injury.2 The I/R combination causes numerous and collateral reactions in tissues, culminating in the alteration of essential molecules and organelles in a number of cells including components of the coronary endothelium and myocardium with the recruitment of circulating blood elements, eg, leukocytes and platelets

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