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Mild nausea or gut flushing: Rare, most often in patients starting at a higher dose than recommended
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The formulation is intended for I.M./I.V
Very small individuals (under 50kg) might start at the lower end of dose ranges
The Increlex (mecasermin) FDA label, which covers native rhIGF-1 in pediatric severe primary IGFD, is the closest human reference and informs the contraindications below
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