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The available evidence supports sermorelins long-term safety profile: Published Evidence A study in the Journal of Clinical Endocrinology & Metabolism followed elderly subjects receiving nightly GHRH (1-29) injections (sermorelin) and found sustained increases in GH and IGF-1 without significant adverse effects or pituitary desensitization (Vittone et al., 1997)
Be aware, though, not to exceed a weekly dose of 2 mg as it does not increase the therapeutic benefits and may raise the risk of side effects
After reading through all these, one thing became clear: most blogs and review sites touch on the positives, a few include the negatives, but none of them show the full range of patient experiences
Some people may struggle to absorb enough through food or supplements, making injections a helpful option
Some patients report changes in appetite or food cravings during the transition period, though these effects are generally temporary and related to the physiological adjustments rather than withdrawal symptoms
