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The next generation of regimens may involve combining GLP-1 or dual GIP/GLP-1 receptor agonists with other nutrient-based hormone receptor agonists or antagonists that offer equal or greater effectiveness with fewer gastrointestinal adverse effects

A positive test would result in a significant sanction

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Asterisks indicate significant difference (P0.05) from control values, # indicate significant difference (P0.05) from ASA treated group and indicate significant difference (P0.05) as compared to BSO+ASA treated group

100 In addition, a high-fat diet and short-chain fatty acids (the metabolites of the gut microbiota) can alter intestinal permeability, which is a characteristic of human T2D