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Following the intervention, 14 (23.3%) had a normal condition, 13 (21.7%) mild, 19 (31.7%) moderate, and 11 (18.3%) had severe depression scale at the 3 rd week of treatment
Given the availability of biomarkers for AD that can be used to measure brain pathology in vivo (including neuroimaging with positron emission tomography, CSF, and plasma biomarker analysis), studies are needed in older adults which measure AD biomarkers in the context of melatonin use
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