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Studies of another thiol-containing antioxidant N -acetylcysteine (NAC), at its intrinsic pH, showed that it destabilizes the biofilm matrix by chelating divalent cations (e.g., Ca 2+ and Mg 2+ ), inhibition of bacterial extracellular polysaccharide production, modulation of bacterial cell physiology and the impact on its metabolism ( Our investigation of H 2 O 2 production by GSH during disruption and killing of MRAB biofilms produced interesting results (Figures 5CE)

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HRR HR deficiency is characteristic of many HGSOC cases (approximately 50%) and is considered a predictive biomarker of sensitivity to platinum agents and PARPis [42]

To test this data interpretation, we analyzed the GSSG-dependent oxidation of reduced fusion constructs between roGFP2 WT and wild-type PfGrx (PfGrx WT ), the dithiol mutant PfGrx C88S , or the monothiol mutant PfGrx C32S/C88S (Fig