The TriNetX platform has been used in retrospective cohort studies [25,26,27,28,29,30,31,32,33,34,35,36,37,38] including evaluating risk and health outcomes of patients with substance use disorders including CUD [25, 32, 35] and the associations of GLP-1RAs with cancer [37] and semaglutide with suicidal ideations [38]
These interactions suggest that targeting a single mode of cell death may be insufficient to fully attenuate tubular injury
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It is important for heart and brain function, muscle movement, and many other body processes
These structural features collectively support the rationale for this specific pairing, though again, all discussed benefits reflect preclinical characterization and mechanistic principles rather than established clinical outcomes