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*Individual results may vary, and no guarantee is provided

RNA sequencing analysis RNA (1 g) per sample was used for sequencing libraries generation by using KAPA mRNA HyperPrep Kit (KAPA Biosystems, Roche, Basel, Switzerland) following the manufacturers recommendations to remove ribosomal RNA

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[24] [25] For carefully selected patients with obesity and inadequate response to medical management, bariatric surgery remains the most effective intervention for sustained weight loss and metabolic improvement