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We also found that neutrophil spEVs suppressed reactive oxygen species (ROS) production by neutrophils, delayed ROS production by monocytes, reduced IL-8 production by other neutrophils and monocytes, increased the viability of monocytes differentiating into macrophages, while increasing neutrophils TGF-beta production, all reflective of anti-inflammatory characteristics 6,11,12,13

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This natural behavior benefits the overall health of the surrounding ecosystem