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Additionally, the enzymes bacterial origin necessitates a rigorous evaluation of immunogenicity, potentially requiring protein de-immunization or immunomodulation strategies if repeat dosing is required

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it can be desirable to purify sub-populations of leukocytes, and methods for doing so, such as density or affinity gradients, flow cytometry, fluorescence Activated Cell Sorting (FACS), immuno-magnetic separation, "panning, and the like, are described in the available literature and below