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De manera similar, en una cohorte de 30 pacientes con HS el tratamiento con semaglutida (dosis media de 0,8mg semanal) durante 8 meses mostr una mejora en las lesiones cutneas y calidad de vida41
Conjugation of a fatty acid chain via hydrophilic linkers to lysine residue at the C20 position prolongs its half-life and enables onceweekly subcutaneous administration [62]
Receptor downregulation after 810 weeks of continuous use necessitates cycling protocols (8 weeks on, 4 weeks off) to maintain response magnitude
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