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Weeks 2-4: When Weight Loss Becomes Measurable By week 2, appetite suppression intensifies for most patients, and calorie reduction becomes easier to sustain without hunger
The honest framing has three parts: This is mechanistic reasoning, not a demonstrated effect
There are no special cases
The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)
2024;14(3):e12651
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