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In light of the narrow therapeutic window defined by the balance between glucose-lowering efficacy and (so-called) gastrointestinal side effects, it seems unlikely that future long-acting GLP-1 receptor agonists will provide substantially greater efficacy without inducing more side effects compared with the already available compounds
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Dosage May Increase Gradually Treatment plans often begin with lower doses that are increased over time
It also plays a crucial role in the production of endothelium-derived relaxing factor (EDRF) , primarily nitric oxide
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