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Give your doctor a complete list of your medications, including prescription drugs, over-the-counter medicines, dietary supplements, and herbal remedies

For those with hypermobility and EDS specifically, Id flag the following as the minimum due diligence before starting these medications: A thorough GI history and ideally gastric emptying assessment if theres any existing dysmotility Baseline muscle mass measurement (DEXA or similar) given the sarcopenia risk A clear plan for high-protein diet and resistance-based exercise to mitigate muscle loss Baseline bone density if theres any existing concern Consideration of the nutritional picture specific to hypermobility, since these drugs can affect appetite and nutrient absorption A conversation specifically about MCAS if thats a feature of your presentation The medication options for hypermobility and EDS are limited and often unsatisfying, and its entirely understandable why people are looking at something new with genuine curiosity

They were high-stress, sleep-starved, and increasingly hopeless

1 Metabolic diseases like obesity and overweight have traditionally been treated with combinations of behavioral therapy and pharmacotherapy, the latter of which was often associated with poor efficacy and weight regain after medication cessation

When used with insulin or sulfonylureas, there is an increased risk of hypoglycaemia, and dose reduction of these medications may be needed