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The central melanocortin effects mediated by MC3R and MC4R the receptor subtypes most strongly retained in PT-141's binding profile include effects on autonomic nervous system activity, energy balance, and aspects of centrally-regulated physiology that have been studied in the context of MC3R/MC4R function in the hypothalamus and brainstem

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The blend is used in research on the hypothalamic-pituitary growth hormone axis

10.1124/jpet.110.175091 12 ChuY.XuY.YangW.ChuK.LiS.GuoL