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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig
Key Functional Differences: NAD+: For energy production and DNA repair Glutathione: For antioxidant defense (fighting free radicals and regenerating other antioxidants) and detoxification NAD vs Glutathione: How They Work Should You Choose NAD or Glutathione
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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve
