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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)

In one study, older adults with early-stage dementia who took vitamin B12 supplements to lower their blood homocysteine levels showed a slower rate of cognitive and clinical decline

For injection technique guidance, see the subcutaneous vs intramuscular injection guide

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