Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma
Of the plethora of articles retrieved from the second MEDLINE search, we identified 28 systematic reviews of animal stud-ies, [39-41] GSH-related genetic polymorphisms linked to various cancers (colorectal can-cer, [42] leukaemia, [43,44] lung cancer,[ 45,46] bladder cancer, [47] gastric cancer, [48,49] prostate cancer, [50-53] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12, 13] hypertension, 56,57 respiratory diseases, [58,59] cataract, [60] myelodysplastic syndrome, [61,62] glioma [63] and male idio-pathic infertility.[ 64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy-induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum)
Caution applies when combining multiple interventions simultaneously
Sleep-Linked Endocrine Rhythms and Neuroendocrine Timing A more specialized application concerns neuroendocrine timing and the relationship between growth hormone secretion and sleep architecture
However, a subgroup of patients may show overlapping problems involving undermethylation, low methylation reserve, oxidative stress and impaired mitochondrial resilience
