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Growth Hormone: Your Body's Most Potent Fat-Burning Hormone Growth hormone directly triggers lipolysis (fat breakdown) through several pathways: Activates hormone-sensitive lipase the enzyme that breaks down stored triglycerides into free fatty acids Increases fatty acid oxidation your mitochondria burn more fat for energy Reduces lipogenesis less dietary fat gets stored in adipose tissue Improves insulin sensitivity better glucose metabolism means less fat storage Why Declining GH Makes Fat Loss So Difficult After age 30, natural GH production declines approximately 14% per decade