1 Introduction Post-translational modifications (PTMs) alter proteins after translation, regulating structure, activity, localization, stability, and interactomes (1)
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Progress in biomarker, neuroimaging, and data-science, evolution and implementation of adaptive trial designs, and back-translation from clinical to molecular insights are accelerating the trajectory toward true and clinically effective disease modification
A sensitivity analysis excluding the ITCA trial yielded a similar point estimate, although statistical significance was not retained (HR (95%CI): 0.87 (0.751.01)