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(R Foundation for Statistical Computing, 2020)
Hsd11b1 and Hsd11b2 cooperatively regulate intracellular glucocorticoid activity: Hsd11b1 catalyzes the activation of inactive cortisone to cortisol, whereas Hsd11b2 inactivates cortisol by converting it to cortisone
Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22
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