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In the SUSTAIN 6 trial of subcutaneous once weekly semaglutide, more retinopathy events occurred in the semaglutide group
Brand tirzepatide products Mounjaro and Zepbound are not affected by the semaglutide approvals, nor are Wegovy or Rybelsus at this stage
Once the vial arrives and is punctured for first use, refrigeration at 28C becomes mandatory for the remaining 28-day use period
In AWARD-10 [31], a 24-week, randomized, double-blind, placebo-controlled trial evaluating once-weekly dulaglutide (administered at either 1.5 or 0.75 mg) as add-on therapy to SGLT2is in a total of 424 patients with inadequately controlled T2DM, only one episode of severe hypoglycemia was reported throughout the study, in a patient treated with dulaglutide 0.75 mg, confirming the very low incidence of serious hypoglycemia with GLP-1RAs in combination with SGLT2is [31]
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