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Oncotarget 6:2200622027 Esworthy RS, Mann JR, Sam M, Chu FF (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage
Similarly, carnitine/acetyl-L-carnitine has been used in treatment of degenerative neuronal function in older Down's Syndrome patients since upon autopsy it was revealed that almost 100% of these patients over 40 years of age had symptoms of dementia [117]
J Neurochemistry 35:12421245 Kumar C, Igbaria A, D'Autreaux B, Planson AG, Junot C, Godat E, Bachhawat AK, Delaunay-Moisan A, Toledano MB (2011) Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control
The shift increases alcohol breakdown but also generates large amounts of reactive oxygen species (ROS), contributing to tissue damage during chronic drinking
