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Importantly, neuroinflammatory processes are closely intertwined with oxidative stress and mitochondrial dysfunction, as inflammatory mediators increase reactive oxygen species production and compromise mitochondrial bioenergetics, further amplifying neuronal vulnerability (33)

Prebiotics are plant fibers that act as fertilizers for the growth of the good bacteria in the gut

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In mouse models, dual agonism had superior efficacy for weight loss and glucose control compared to a GLP-1RA alone 9 , with additive effects of the GIPR proposed to act through signaling in beta cells 10 , alpha cells 11 , the CNS (central nervous system) 12,13 and adipocytes 14