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Kuemmerle, K
Deng T, Lyon CJ, Bergin S, Caligiuri MA, Hsueh WA
GLP-1 receptor agonists begin working at a physiological level shortly after administration , but the clinical effects patients notice develop more gradually over days to weeks
They are often due to: Immune response to the peptide itself Histamine release at the injection site Irritation from benzyl alcohol, preservatives, or buffers Needle trauma or poor injection technique Using the same site repeatedly without rotation Suboptimal reconstitution (too concentrated or acidic solution) Contaminants in low-quality peptides from unregulated sources The body may react to peptidesespecially new onesas foreign substances, causing a mild inflammatory or immune response
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