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In muscle and adipose tissue, GLP-1RA increases insulin sensitivity, promotes glucose uptake and utilization, and reduces the release of free fatty acids (FFA) produced by fat breakdown

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For instance, HFDS-induced obesity reduces the production of granzyme and cytokines (TNF-, TNF-), which in turn causes the depletion of CD8+ tumor-infiltrating lymphocytes (TILs) and ultimately speeds up tumor growth in a mouse model of colorectal cancer [37,38,39]

Semaglutide was an ideal candidate for oral delivery with SNAC due to its low molecular weight (4,113.6 Da), long half-life (~ 7 days after subcutaneous administration), and high potency relative to other peptides [14, 40, 46, 56]

Many patients start with one GLP-1RA therapy and switch to another for various reasons